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KMID : 0380620190510040361
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 4 p.361 ~ p.368
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Effects of Dendropanax morbifera extracts on postmenopausal syndrome in ovariectomized rats
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Oh Ga-Hui
Oh Sung-Moon
Lee Seung-Sik
Kim Ji-Hyeon
Park Young-Joon
Kim Joo-Eun
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Abstract
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The present study aimed to evaluate the effect of Dendropanax morbifera (DM) extract on postmenopausal syndrome and to develop DM extract as an alternative for hormonal therapy. The following seven groups of rats; normal control (sham), ovariectomized (OVX) control, Punica granatum (PG)-treated group (770 mg/kg), estradiol treated group (0.5 mg/kg), and three DM-treated groups (200, 500, 1000 mg/kg) were compared. Indicated compounds were administrated once a day for eight weeks. To evaluate the estrogenic effect of DM extract, western blot analysis was performed on the liver tissue to confirm the expression of estrogen receptor (ER-α, ER-β). Our analysis showed that after DM administration, collagen cross-linked C-telopeptide (CTX) value decreased while ER-α protein expression increased in a dose-dependent manner through the MAPK/ERK pathway in OVX rats. These results suggest that Dendropanax morbifera exerts estrogenic effect by inducing estrogen receptor expression and activating MAPK/ERK pathway.
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KEYWORD
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Dendropanax morbifera, phytoestrogen, rutin, ovariectomized rats, menopausal syndrome
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